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STAU2 regulates the balance of neural stem cell maintenance versus differentiation during development [ 94], modulates long term depression by directing dendritic localization of protein synthesis in hippocampal neurons [ 95], and stabilizes the RNA of dendritic and synaptic proteins including RGS4 (regulator of G protein signaling 4) [ 80].
Nonetheless, the simple temperature control as observed in this global dataset implies that basalt weathering could be an effective mechanism for Earth to modulate long-term carbon cycle perturbations.
The 5-day study was not long enough to modulate long-term indices of glycemic control such as glycated hemoglobin.
The most plausible interpretation of these observations is that fish do not modulate long-term behaviour in order to allow injury repair.
This in turn can modulate long-term potentiation (LTP) (Castillo et al., 2011; Fritsch et al., 2010), which is known to be mediated by NMDA-receptor activity (Nitsche et al., 2003).
Thus, immediate regulation of cellular processes by ceramides and other sphingolipids may be mediated by salvaging pathways, whereas de novo synthesis of sphingolipids may modulate long-term cellular processes.
93 GLP-1 analogs have been demonstrated to exert neuroprotective and aniapoptotic effects, reduce Aβ plaque accumulation, modulate long-term potentiation and synaptic plasticity, and promote the differentiation of neuronal progenitor cells.
The cholesterol biosynthetic pathway also is important for learning/plasticity because of its role in generating membrane for neurite outgrowth and because it provides isoprenoids that modulate long-term potentiation (90, 93).
The cation can critically modulate long-term potentiation and depression by interfering with the functioning of N-methyl--aspartate and γ-aminobutyric acid receptors and recent findings also indicate that Zn2+ can act on the ZnR, a post-synaptic metabotropic Zn2+-sensing receptor, which activates MAPK and CAMK2 and ultimately affects synaptic plasticity.
In rat prefrontal cortex, dopamine strongly modulates long-term depression (LTD) and potentiation (LTP) of glutamatergic synapses.
Considering the interaction of neurabin with PP1, it is reasonable to believe that neurabin is important in targeting PP1 to the dendritic spine, thereby modulating long-term plasticity.
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