Sentence examples for modulate lifespan in from inspiring English sources

PKA and Sch9 are also well known to modulate lifespan in various organisms [ 8].

More significantly, 4 of the 13 putative O-GlcNAc target proteins have been reported to modulate lifespan in C. elegans.

We demonstrate that the O-GlcNAc cycling enzymes OGT and OGA, which add and remove O-GlcNAc respectively, modulate lifespan in C. elegans.

Collectively our data demonstrates that mir-71 acts at least partly in parallel to insulin/IGF type signaling to modulate lifespan in C. elegans.

This information guided the selection of 93 candidate genes which were tested for their ability to modulate lifespan in a unicellular model system (yeast chronological lifespan) to study organismic ageing [ 28].

Here we review the effects of calorie restriction in different model organisms and the molecular mechanisms by which dietary interventions may modulate lifespan in simple model organisms and mammals.

Sir2, a NAD-dependent deacetylase, modulates lifespan in yeasts, worms and flies.

Insulin/IGF like signaling modulates lifespan in many model organisms ranging from worms to vertebrates [ 23- 27].

In this study, we characterized the molecular mechanisms by which one component of this complex, PAT-4/ILK, modulates lifespan in C. elegans.

Importantly, IGF-I in the brain modulates lifespan in mammals (Holzenberger et al., 2003; Kappeler et al., 2008) and is also a powerful cell proliferation, differentiation, and survival factor (Aberg et al., 2000; Kalluri et al., 2007).

A particularly interesting food-related response is the role of dietary restriction (DR) in modulating lifespan in diverse species (Bishop and Guarente, 2007; Mair and Dillin, 2008; Fontana et al., 2010; Alic and Partridge, 2011).