Sentence examples for modulate life span from inspiring English sources

— but we've now found about five hundred and fifty genes in the worm that modulate life span.

The exposure to nutrient-derived odorants in Drosophila was shown to modulate life span in an Or83b dependent manner [72].

These observations have also raised the important question, what are the downstream function(s) of TORC1 that modulate life span?

This pathway also enables integration of signals from the reproductive system with DAF-16 activation to modulate life span [ 28- 30].

Furthermore, we found that removal of the cytoplasmic endosymbiont Wolbachia, which can modulate life span of some Drosophila mutants (Ikeya et al., 2009; Toivonen et al., 2007), did not affect extension of life span by rapamycin.

Sophisticated genetic approaches have resulted in the identification of many genes that modulate life span and/or reproductive span, providing insight into the genetic control of somatic and reproductive aging (Huang et al. 2004; Hughes et al. 2007; Andux and Ellis 2008; Luo et al. 2009; Kenyon 2010; Luo et al. 2010; Mendenhall et al. 2011).

The apparent paradox of how p53 modulates life span will undoubtedly resolve as we understand in greater detail how p53 and its activities impact specific aging phenotypes.

Liganded DAF-12 promotes longevity in all contexts tested, whereas unliganded DAF-12 modulates life span in a context-dependent manner; in the context of reduced DAF-2/InsR signaling via daf-2 RNAi, unliganded DAF-12 promotes longevity.

To address this, we used two interventions that modulate Drosophila life span robustly, and tested their effects on mitochondrial H2O2 levels.

In aging Drosophila, abnormal apoptotic events have been observed in muscle and fat tissue [ 8], but the extent to which apoptosis (or cellular senescence) might modulate Drosophila life span remains largely unknown.

As a key catabolic process in degradation of damaged organelles and harmful protein aggregates, autophagy is thought to act downstream of these signaling pathways to modulate the life span of the organism.