This Pirh2-mediated posttranscriptional regulation of p63 may modulate keratinocytes differentiation [ 47].
Experiments with agonists and specific inhibitors of the four known histamine receptors (H1R H4R; (29)) showed that histamine modulates keratinocyte differentiation via activation of H1R.
This bioactive phospholipid has been shown to modulate keratinocyte growth and differentiation 19 and signals through members of the LPA1 3 family of GPCRs.
One regulator is p300, which has been shown to modulate p21Waf1/CIP1 promoter activity during mouse keratinocyte differentiation [14] and has also been shown to regulate muscle cell differentiation in a MyoD dependent pathway [15], [16].
Furthermore, keratinocytes not only produce and metabolize the vitamin D precursor [63], but keratinocyte differentiation is in turn modulated by vitamin D and is essential for maintaining healthy skin [64, 65].
Furthermore, keratinocytes not only produce and metabolize the vitamin D precursor [ 63], but keratinocyte differentiation is in turn modulated by vitamin D and is essential for maintaining healthy skin [ 64, 65].
MiRNA-mediated suppression of SOCS-3 expression in keratinocytes may therefore not only modulate cytokine signaling but also contribute to keratinocyte hyperproliferation and alteration in keratinocyte differentiation in psoriatic plaques.
As HSPG was supposed to modulate proliferation and differentiation by its ability to affect growth factor signaling and binding, heparanase could play an important role in keratinocyte differentiation by acting on heparan sulfate.
miR-200c exerts negative effects on keratinocyte migration and positive effect on keratinocyte differentiation.
