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Spermine is an endogenous polyamine; possesses anti-oxidant property and has ability to modulate ion channels and NO synthase activity.
However, whether flotillin-1 can modulate ion channels on cell membranes has yet to be shown.
Mouse Piezo1 (MmPiezo1) and MmPiezo2 (also called Fam38a and Fam38b, respectively) induce mechanically activated cationic currents in cells; however, it is unknown whether Piezo proteins are pore-forming ion channels or modulate ion channels.
However there is empirical support for the significance of ion channels for the clinical symptoms of BD; both Lithium [10], [11] and antiepileptics that have long been successfully used for the treatment of BD are now known to modulate ion channels [12].
These observations indicate that proteins in group II may modulate ion channels, such as maxiK channels.
NGF is also thought to alter expression of neurotransmitters, modulate ion channels, and increase excitability of afferent nerves [ 57].
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As plasma membrane components, gangliosides are known to modulate ion channel function11 and receptor signaling, both of which are key for regulating neuronal excitability.
In addition, a large number of therapeutic drugs, including local anesthetics, benzodiazepines, and sulfonylurea derivatives, act directly or indirectly to modulate ion channel activity.
Although many optogenetic approaches are designed to modulate ion channel conductivity, we mainly examine systems that target other biomolecular reactions such as gene expression, protein translocations, and kinase or receptor signaling pathways.
The cytoskeleton of the cardiomyocyte has been shown to modulate ion channel function.
In part, anaesthetics modulate ion channel function by disturbing the lipid bilayer.
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