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Our data show that retinoic acid can modulate invasiveness in opposite directions.
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Since these results suggest that CapG modulates invasiveness in OC cell lines, we further strived to explore molecular mechanisms that contribute to CapG functioning.
Using a gene targeting approach, Nanda et al (2006) have shown that endosialin is dispensable for normal development and subcutaneous tumour growth, but can modulate invasiveness and metastatic progression in an orthotopic xenograft model of colorectal cancer.
Elevated pathway activity furthermore distinguishes metastatic from localized prostate cancer, and pathway manipulation can modulate invasiveness and metastasis.
Levels of CEACAM6 expression can modulate pancreatic adenocarcinoma cellular invasiveness in a c-Src-dependent manner.
84 Interestingly, miR-106b modulates TWIST1 expression and invasiveness in endometrial cancer cells.
Matrix metalloproteinase activity modulates tumor size, cell motility, and cell invasiveness in murine aggressive fibromatosis.
The results herein presented point to the existence of a Notch-mediated mechanism able to positively modulate the expression of adhesion proteins, such as N-cadherin and α9-integrin, which may drive motility and invasiveness in neoplasic cells, thereby permitting cancer progression.
The interaction between GBM CSCs and different cell types that reside in the microenvironment may modulate CSC invasiveness and intrinsic drug resistance.
Klironomos, J. N. Feedback with soil biota contributes to plant rarity and invasiveness in communities.
To characterize fascin-1 expression in urothelial neoplasms and its correlation with invasiveness in urothelial carcinomas.
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