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The anti-inflammatory activity exerted in vivo by 8-oxoGTP or 7,8-dihydro-8-oxo-deoxyguanosine (but not by 8-oxoG) indicates that some oxidation by-products can modulate immune functions [34], [35].
It is expected that selective CB2 agonists act as therapeutic agents that modulate immune functions without any psychoactive effects.
By increasing the count of neutrophils and eosinophils, Li inhibits T-cell production, and is sometimes used to modulate immune functions (reviewed by ).
Therefore, they are involved in aspects of both innate and adaptive immune systems and can modulate immune functions, reverse immune suppression, and decrease tumor immune tolerance and therefore terminate low immunoreactivity in tumor patients [ 13].
Furthermore, the pathways that control immune cell function and metabolism are intimately linked and this relationship might intriguingly provide new strategies to modulate immune functions in several infectious diseases [ 35, 36].
The ability to modulate immune functions by probiotic bacteria and the ability to metabolize carcinogen agents as well as the buffering capacity exerted against the pathogenic strains are amongst several of many roles that the colon microflora performs.
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Genetic immunotherapy approaches include the transfer of genes encoding cytokines and costimulatory molecules to modulate immune function, as well as genetic immunization strategies which rely on the delivery of cloned tumor antigens.
These data suggest that the concentration of curcumin required to modulate immune function could not be reached using dietary strategies.
Nicotine is known to modulate immune function, but reports have produced conflicting evidence as to whether nicotinic acetylcholine (nACh) receptors are responsible for these effects.
In the recent years, there is an increasing interest in the use of herbal extracts for disease control and prevention in aquaculture, indicating that they can modulate immune function in farmed species.
In conclusion, we have provided evidence that endogenous metallothionein can modulate the immune response in vivo and that intracellular MT may modulate immune function by regulation of transcription factor activity.
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