Sentence examples for modulate immune activation from inspiring English sources

Genetic predisposition and environment interactions also potentially modulate immune activation, these possibilities are currently under investigation.

Treg modulate immune activation to prevent pathological self-reactivity [ 28, 36].

We reasoned that, in light of their immunoregulatory function, NKT cells have the potential to play a role in modulating immune activation during HIV and SIV infection.

Pharmacological attempts at modulating immune activation in HIV disease with the goal of increasing CD4T cells counts with corticosteroids, cyclosporine, cyclooxygenase 2 inhibitors, mycophenolate mofetil and chloroquine have either been unsuccessful or demonstrated only modest benefits in short-term surrogate endpoints.

As a secreted protein, ISG15 has been shown to primarily modulate immune cell activation [ 15].

Indeed, variation in regulation may strongly modulate the negative outcome of immune activation, with potentially important fitness consequences.

Cyclic dinucleotides act as intracellular second messengers, modulating a variety of cellular activities including innate immune activation.

BMMSCs and WJMSCs could probably influence lymphoproliferation responses uniquely by differentially modulating the levels of key immune activation markers which contribute to the development of the immune response.

Whether persistence of functionally intact systemic NKT cells helps to down-modulate and maintain low levels of immune activation in nonpathogenic natural SIV infection remains to be determined.

In addition, the expression of TNF and IL-1 receptors on Tregs may have important functions in modulating their differentiation or homeostasis during chronic immune activation or inflammation.

Therefore, dissection of the underlying mechanisms of immune activation when NFκB is modulated in the cells might help design strategies to target each disease accordingly.