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Firstly, it releases quantities of 'excretory secretory' products which include lectins, mucins and enzymes that interact with and modulate host immunity.
Therefore, comparison to the MIC and the EC50 in the C. elegans assay may be used to identify compounds that have higher efficacy during infection than in vitro, as such compounds may affect virulence factors or modulate host immunity.
We focused our investigation on the ability of B. pertussis to modulate host immunity, in particular on the role played by adenylate cyclase toxin (CyaA), an important virulence factor of B. pertussis.
In light of these data, we hypothesized that adoptive cell therapy using host-type Th2.R cells may represent a novel approach to modulate host immunity towards a Th2 phenotype for prolongation of solid organ transplant survival.
To test the hypothesis that ALT proteins modulate host immunity, we adopted an alternative transfection strategy to express these products in the protozoan parasite Leishmania mexicana.
They suggested that some of these CSEPs could still be involved in interactions with host RNAs and modulate host immunity via this route.
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Protein effectors of pathogenicity are instrumental in modulating host immunity and disease resistance.
Certain classes of effectors, such as ones modulating host immunity, are believed to rapidly change to overcome resistance, however, the mechanisms generating this variation are not known.
Therefore, these transgenic fish are ideal experimental animals for addressing the question of how cecropin P1 modulates host immunity or other genetic traits and confers them resistant to infection by pathogens.
Our previous reports demonstrate the use of macroporous PLG scaffolds for generating 3D microenvironments to modulate host immune cells to induce effective antitumor immunity.
Oomycete plant pathogens, such as P. infestans, secrete an arsenal of effector proteins that modulate host innate immunity and enable parasitic infection [8].
More suggestions(15)
modulate pulmonary immunity
modulate tumor immunity
modulate host metabolism
modulate host defence
modulate host plant
modulate host cell
modulate host nitrogen
modulate mucosal immunity
modulate host physiology
modulate host hemostasis
modulate host defense
modulate host response
modulate host microRNA
alter host immunity
influence host immunity
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