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Our previous reports demonstrate the use of macroporous PLG scaffolds for generating 3D microenvironments to modulate host immune cells to induce effective antitumor immunity.
H. pylori is known to utilize specific molecular mechanisms to modulate host immune response and create a local micro-environment that aids its colonization5,11.
While host cells elaborate diverse mechanisms for pathogen expulsion, amebae have also developed complex strategies to modulate host immune response and facilitate their own survival.
Orthopoxviruses encode multiple proteins that modulate host immune responses.
Functional studies revealed that these viral miRNAs regulate EBV latent infection and modulate host immune responses by targeting a variety of viral and cellular genes.
On the other hand, BHRF1-3 has been shown to modulate host immune responses by targeting the interferon-induced chemokine CXCL11 [14], while BART2-5p thegets thostostress-inducedced Natural Killer cell ligand, MICB, to escape recognition and consequent elimination by NK cells [15].
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Emerging data also indicates the role of immune tolerance mechanisms and impact of several product-related factors on modulating host immune responses.
The host immune defense to implants is proved to greatly influence the osteogenesis and new bone formation, but up to now, few studies are focused on the silicate bioceramics modulated host immune responses.
Intestinal fungi are an important component of the microbiota, and recent studies have unveiled their potential in modulating host immune homeostasis and inflammatory disease.
An RNA virus of a parasite binds to human Toll-like receptor 3 and modulates host immune responses to the parasite.
These molecules are associated with modulating host immune cell interactions, and may have a role in eliciting sepsis.
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