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We demonstrate that the PPGT substrates can modulate hMSC morphology, growth, and differentiation, and that they can produce similar outcomes as observed for a non-degradable polyacrylamide substrate, confirming their utility as a degradable elastomer for tissue engineering and other biomedical applications.
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Aged hMSC morphology and its heterogeneity are modulated by surface energy.
Surface energy was shown to regulate aged hMSC morphology, survival, and proteoglycan expression.
Seeding fibrous SF scaffolds with human mesenchymal stem cells (hMSCs) demonstrated that fiber alignment could guide hMSC morphology and orientation demonstrating the impact of scaffold topography on the engineering of oriented tissues.
In another example, Guvendiren and Burdick used micro-scale hydrogel surface wrinkles to modulate hMSC response by changing surface wrinkle size and shapes.
However, PD-PLLA fibers modulated hMSC responses in several aspects.
Using self-assembled monolayers of ω-functionalized alkanethiols on gold as model substrates, we demonstrate that biomaterial surface chemistry differentially modulates hMSC differentiation in a lineage-dependent manner.
After in vitro differentiation, HMSCs morphology changed into typical neuroglial-like pattern with multibranches and secondary branches).
However our PCL CNT nanocomposites were able to sustain osteoblast proliferation and modulate cell morphology.
MMP-7 has also been shown to modulate synapse morphology.
Fibulin family has been shown to modulate cell morphology, growth, adhesion and motility.
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