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The GABAB receptor antagonist, CGP55845, did not modulate glucagon secretion at either low or high glucose concentrations (Fig. 5d).
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45, 50 In these circumstances, hypoglycemia would not be expected to occur, because GLP-1 receptor agonism modulates insulin and glucagon secretion in a glucose-dependent manner.
Our data show that pancreatic α cells respond to glucose with closure of KATP-channels and suggest that glucose modulates KATP-channel activity and glucagon secretion via increased cytoplasmic ATP/ADP.
GLP-1 also modulates the function of α-cells as it inhibits glucagon secretion in a glucose-dependent way.
Given that dysregulation of insulin and glucagon secretion are characteristics of type 2 diabetes, we propose that PASK may be a potential drug target to modulate glucagon release in vivo.
The two main defenses to hypoglycemia are an increase in glucagon secretion and adrenaline secretion [17].
It suppresses postprandial glucagon secretion and slows gastric emptying.
Glucagon-like peptide 1 (GLP-1) is secreted from enteroendocrine L-cells in response to oral nutrient intake and elicits glucose-stimulated insulin secretion while suppressing glucagon secretion.
Glucagon secretion and gene expression increased in islets isolated from biotin-deficient mice.
GLP-1 reduced glucagon secretion in both types of islets (Fig. 2a).
GLP-1 may further limit glucose appearance through the suppression of glucagon secretion [27].
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