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MicroRNAs (miRNAs) are small, non-protein-coding RNA molecules that modulate gene translation.
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They function by targeting multiple transcripts to epigenetically modulate the gene translation rate and induce messenger RNA (mRNA) degradation depending on the strength of binding to 3′ untranslated region (3′UTR).
miRNAs are predicted to control the activity of more than 30% of human genes [ 5]. miRNAs are transcribed as ~70 nucleotide stem-loop precursors and subsequently processed by the cytoplasmic RNase-III type enzyme Dicer to generate ~22 nucleotide mature products which can target and modulate gene expression by inhibiting translation and/or inducing degradation of target mRNAs [ 4, 6, 7].
MicroRNAs (miRNAs) modulate gene expression by inhibiting the translation or promoting the degradation of target mRNAs.
MicroRNAs (miRNAs) are a group of endogenous ~22 nt small non-coding RNAs that can modulate gene expression by inhibiting mRNA translation or regulating mRNA degradation at the post-transcriptional level [ 1].
miRNAs modulate gene expression by inhibiting mRNA translation or regulating mRNA degradation at the post-transcriptional level based on pairing between the 5' end of the miRNA (i.e., 2-8 nthethe"seed"region) and the 3' untranslated regions (3' UTR) of target mRNAs [ 1, 38– 40].
Based on recent developments in understanding miRNA biology and mechanisms, at least three main models can be proposed by which miRNAs could modulate gene expression post-transcriptionally: (1) inhibition of translation initiation, (2) postinitiation inhibition of translation, and (3) mRNA destabilization.
MicroRNAs are short RNA molecules that modulate gene expression post-transcriptionally by repressing translation or degrading the mRNA transcript [ 26].
MicroRNAs (miRNAs) are short (about 22 nucleotides in length) single-stranded regulatory RNAs that modulate gene expression at the posttranscriptional level by repressing translation of specific messenger RNA (mRNA) targets, eventually resulting in downregulation of protein expression.
miRNAs are a class of small noncoding RNA molecules that modulate gene expression by binding to specific target messenger RNAs to prevent their translation and/or to promote degradation.
Translational elongation and translation were related to gene translation process.
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