Residues corresponding to an N-[VI] motif that is conserved within Arf/Arl GTPases may play a role in the interswitch toggle characteristic of the Arf family, whereas other, co-conserved residues may modulate the flexibility of the guanine binding loop.
Unlike the effect of the H-bonds across the loop, significant spectral shifts arise from modulating the flexibility of the CXXCH arm, in particular the δ(Ca S1 C PyrI internal coordinate from Cys12, and the torsional and bending modes of His16.
Since glutamine is more hydrophilic than arginine, the amino acid substitution may affect the relative position of the two functional domains by modulating the flexibility of the linker connecting them [ 57].
The D3 domain of flagellin was replaced with one or more RGD motifs linked by various oligopeptides modulating flexibility and accessibility of the inserted segment.
These results collectively indicate that microenvironmental factors can uniquely modify the phenotype of differentiated recruited monocytes inducing marked changes in mRNA levels and also in miRNA expression and kinetics that may modulate the remarkable flexibility of monocyte responses to specific environmental cues.
Snf5 subunit plays a critical role in modulating the ARP mobility and its deletion results in boosting the flexibility of the ARP module (Fig. S6C).
On the other hand, the base composition also influences the shape and flexibility of the DNA, thereby modulating the strength of the interactions.
This raises the interesting possibility that both time and reward value modulate the firing of serotonergic neurons, increasing the flexibility of the serotonergic signal.
In addition, Ackerley et al. have shown that p38α phosphorylates NF-M and NF-H on their side-arm domains in cortical neurons, thereby modulating the flexibility and stability of the cytoskeleton [29], [54].
This study highlights the flexibility of integrins as receptors in terms of their ability to modulate their affinity in accordance with function and independently of expression on the cell membrane.
