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Thus, these data suggest that EAF1 and EAF2/U19 bind directly to the Wnt4 promoter to modulate expression levels.
Homeodomain proteins are transcription factors that modulate expression levels of their target genes [ 3, 4].
The breast cancer association consortium BCAC has hypothesized that the low-risk SNPs modulate expression levels of nearby located genes.
They proposed an alternative disease mechanism, in which SNP genotypes modulate expression levels of nearby located genes.
(83 ) Transcription factors have the ability to modulate expression levels of specific pathways in those cells with the appropriate transcription complex cohort.
Antitubulin chemotherapeutics have been reported to modulate expression levels and post translational modifications of two antiapoptotic BCL-2 family proteins, that is, MCL-1 and BCL-2, during mitotic arrest.
Similar(51)
Non-coding region polymorphisms in cattle have been identified that modulate expression level [2], [3] and influence susceptibility to classical bovine spongiform encephalopathy (BSE) [4], [5] but not atypical BSE [6].
Moreover, simple sequence repeats in the coding region can influence translational selection of genes that can modulate expression level of those genes [ 10].
Downregulation of miR-335 in non-neuronal cells modulates expression levels of HAND1 and JAG1, known modulators of neuronal differentiation.
Silencing of gene expression by such post-transcriptional processes has been identified as a new level of gene regulation which is capable of modulating expression levels.
Better characterization of lncRNAs (structure, functions, polymorphisms, and intracellular topography) could help in faster development of new anticancer strategies modulating expression levels and functions of deregulated lncRNAs.
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modulate miR levels
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