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In addition, Adtrp, Nrpt, E2f8 could also modulate endothelial permeability via interaction with Vegf-b [ 47].
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VE-cadherin has an important function in controlling vascular organization and modulating endothelial permeability [ 46].
A major component of the signalling cascade modulating endothelial permeability is the intracellular level of Ca2+ (Curry, 1992).
VEGF supports proliferation and survival of germ cells [ 29], regulates microcirculation [ 27, 30], and modulates endothelial permeability in testis [ 31].
Our findings suggest that Angptl3 may participate in pathologic processes in dengue virus infection, with a possible role in modulating endothelial permeability, a hallmark of severe dengue.
Endocan [previously called endothelial cell-specific molecule 1 (ESM-1)] is a proteoglycan that is mainly expressed in the pulmonary microcirculation, where it plays an important role in endothelial homeostasis [9, 10], able to modulate cell adhesion, endothelial permeability and leukocyte migration from the circulation into the tissues [11, 12].
AMP-activated protein kinase (AMPK) has been shown to modulate cytoskeleton and could mediate endothelial permeability.
In endothelial cells, Jam-C regulates vascular endothelial permeability by modulating VE-cadherin-mediated cell-cell contacts [ 71].
These authors suggested that BSA reacts with NO therefore modulating its biological actions and increasing endothelial permeability.
BSA reacts with nitric oxide (NO) therefore modulating its biological actions and increasing endothelial permeability (Predescu et al. 2002).
Taken together, these results implicate Tbdn as an important regulator of retinal endothelial permeability and homeostasis by modulating a signaling pathway involving c-Src and Cortactin.
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