Sentence examples for modulate drug sensitivity from inspiring English sources

This difference could be based on the different experimental conditions, which to some extent affect channel regulation and may modulate drug sensitivity.

We examined the ability of dipyridamole (DPM) to act synergistically with vinblastine (VBL) in HT1080 fibrosarcoma cells and a drug-resistant variant, HT1080/DR4, which lacks mdr1 expression, in order to determine whether DPM requires P-glycoprotein to modulate drug sensitivity.

Exposure of both doxorubicin (2780AD) and cisplatin (2780CP) resistant human ovarian cell lines to non-toxic concentrations of polyunsaturated fatty acids (gamma-linolenic acid and eicosapentaenoic acid) either before or during exposure to the cytotoxic drug did not modulate drug sensitivity.

The ability of the proteasome inhibitor MG132 to curtail the synergy between HHT and Dxr is consistent with HHT modulating drug sensitivity by causing loss of short-lived pro-survival factors.

This demonstrates that the drug response and pathway activation signatures can not only be used individually to predict treatment outcomes, but can also be combined for insight into the mechanisms modulating drug sensitivity.

Importantly, reactivation of ASS1 expression by the demethylating agent 5-Aza-dC led to resistance to ADI-PEG20, confirming that ASS1 promoter methylation modulates drug sensitivity in malignant lymphoid cells.

miRNA expression profiles in biological fluids can be potentially used for the detection and surveillance of EOC; however, because miRNAs may also be involved in modulating drug sensitivity, the delivery of miRNA mimetics or antago-miRNAs may affect drug responses to conventional therapies.

Although the mechanism of TPA induced sensitization is not yet fully understood, this study points to a central role for PKCα in modulating platinum drug sensitivity.

Mesenchymal stem cells are, in addition to other cells in the tumour microenvironment, increasingly identified as an important population of cells that modulate tumour progression and drug sensitivity.

While this association suggests that an overlapping set of genes regulates both simple and complex drug behaviors, several exceptions to this correlation exist (e.g. Colombo et al. 2000; Phillips et al. 1998; Boehm et al. 2004), indicating that factors other than acute drug sensitivity modulate drug intake.

Relative specificity, therefore, enables mTORC1 to differentially phosphorylate substrates under the same physiological inputs, which modulates cell behaviors and drug sensitivity.