Sentence examples for modulate drug response from inspiring English sources

Genetic variation in genes known to modulate drug response in general, such as the ABC family of xenobiotic transporters, or the cytochrome P450 detoxification enzymes, has been successfully correlated to clinical outcomes of drug therapy [6] [11].

Variants were then annotated and scanned for associated functions along with SNVs that could modulate drug response.

In analyzing SNPs that modulate drug response, we found a variation that predicts a favorable response to metformin, a drug used to treat diabetes.

Thus, certain dietary components or prebiotics can induce shifts in the gut microbiome and thereby modulate drug responses.

We discuss mechanisms of drug resistance caused by network adaptations and suggest that development of effective drug combinations requires understanding of how feedback loops modulate drug responses.

Herein we employ a functional genetic approach to identify genes that modulate drug responses to MET inhibition in NSCLCs.

Pharmacogenomics is an emerging research field that focuses on the study of how genes modulate drug responses among individuals [ 1, 2].

" Genetic variation modulating drug response: discovery and implementation" Dr. Roden introduced BioVU, a resource that links DNA extracted from clinically-obtained blood samples to their de-identified electronic medical record (EMR).

Additionally, these molecules may represent targets for novel therapeutic strategies, used to overcome chemotherapy resistance in ovarian cancer, thereby modulating drug response in these patients and reducing the mortality rate associated with this disease.

Our study establishes a novel role for SMARCE1 in modulating drug responses through regulating EGFR expression in lung cancers.

These results validate our initial screens, but also indicate that the effect of ARID1A is potentially context-dependent and suggest a major role for SMARCE1 in modulating drug responses to MET and ALK inhibitors in NSCLCs.