We determined that the composition and architecture of the ECM niche modulated drug efficacy.
Pharmacomicrobiomics thus may have at least two global clinical applications: 1) to combine personal microbiome and genetic profiles to better predict an individual's medication response; and 2) to modulate the gut microbiome to improve drug efficacy on the individual level.
To assess drug pharmacological effect, such as drug efficacy and toxicity, we assume that "ideal" drugs for a patient diagnosed with a certain disease should modulate the gene expression profiles of this patient to the similar level with those in normal healthy people.
Drug efficacy was evaluated in patients 2 h post-dose.
There was no evidence to suggest any correlation between different drug doses and drug efficacy.
1) When only the unchanged drug was involved in drug efficacy: .
Nerotrack works with pharma companies and researchers to recruit candidates for clinical trials and to help measure drug efficacy, thereby speeding up the process of drug development.
Therefore, the introduction of thermosensitive polymers on polymeric nanoparticles might be a potential approaches to modulate drug release behaviors.
Since then Canavati has focused her career on drug efficacy and safety trials.
