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Genetic variants may modulate dopamine transporter (DAT) availability in the brain.
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Zhu, J., Ananthan, S., Mactutus, C. F. & Booze, R. M. Recombinant human immunodeficiency virus-1 transactivator of transcription1-86 allosterically modulates dopamine transporter activity.
Altered corticostriatal neurotransmission and modulation in dopamine transporter knock-down mice.
In fact, in a recent study [ 5], we found that the 3'-UTR VNTR polymorphism in the dopamine transporter gene modulates behavioral response to MPH, replicating a previous study by Stein et al. [ 6].
Moritz, A. E. et al. Phosphorylation of dopamine transporter serine 7 modulates cocaine analog binding.
Butler B, Saha K, Rana T, Becker JP, Sambo D, Davari P, et al. Dopamine transporter activity is modulated by alpha-synuclein.
A key player in regulation of DA signalling is the dopamine transporter (DAT), it modulates the dynamics and the levels of DA in the synaptic cleft by recycling extracellular DA back into the presynaptic terminal.
The variants in syntaxin and dopamine transporter each impair reverse transport of dopamine.
Membrane cholesterol modulates the outward facing conformation of the dopamine transporter and alters cocaine binding.
Thus, genetic variants that affect the structure and/or the function of the dopamine transporter may retain reasonable a priori probability to modulate behavioral response to MPH.
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