Sentence examples for modulate disease in from inspiring English sources
The Th2 responses obtained by this route are dominant over Th1 responses induced by antigen in CFA [6], suggesting that epicutaneous immunization with an RA autoantigen could modulate disease in the CCIA model.
Conversely, sFlt-1 has been shown to modulate disease in other in vivo models, including animal models of RA [ 18- 22].
Therefore, we assessed the ability of a cell-permeable Rac1 carboxy-terminal inhibitory peptide to modulate disease in mice with collagen-induced arthritis (CIA).
Alternatively, one might consider attempts to modulate disease in humans by blocking viral protein function with antibody 95 or, if a good case can be made for involvement of a replication competent virus, with antiretroviral drugs.
However, manipulation of 5α-reductase activity with the inhibitor dutasteride failed to modulate disease in SBMA patients (Fernandez-Rhodes et al., 2011) or in a transgenic mouse model of SBMA (Maria Cho, Heather Montie, Mary Rosemiller, Yuhong Liu and D.E.M., unpublished results).
TLR3 in mLN and TLR7 in spleen both systemically modulate disease development in AIPI rats via altering serum IgE concentration relevant to Th2 responses.
While this evidence would support the direct pathogenicity of ANCA, the observation that patients with high-titer ANCA can lack glomerulonephritis and may remain in remission suggests that additional factors modulate disease occurrence in humans.
We aimed to derive correlations between the gene expression changes in PKD and a set of pathways that modulate disease severity in our mouse model and human ADPKD.
Furthermore, biotic interactions may exert natural selection in a manner that depends upon the abiotic context, for example, saline soils can modulate disease pressure in tomato [ 57].
Nonetheless, these results may have implications for the human population, as genotype-diet interactions are known to modulate disease risk in MTHFR 677 C>T individuals (31).
IL-10 is both an immunoinhibitory (monocytes and T cells) and an immunostimulatory (B cells) cytokine that may confer susceptibility and modulate disease expression in rheumatoid arthritis (RA).
