Whether serotonin directly modulates disease course or constitute a surrogate marker of another crucial pathogenic event, our results show that platelet serotonin correlates with survival in ALS.
These observations explain the tremendous effects of ceftriaxone in modulating disease course and accelerating recovery in a model of autoimmune CNS inflammation.
In contrast, we noted that CD7 expression was frequently modulated in tumor cells over the disease course.
In vitro treatment with a Jagged1 agonist peptide modulated the T-cell activation network in PBMCs from patients with MS. Moreover, treatment of mice with experimental autoimmune encephalomyelitis with the Jagged1 agonist ameliorated the disease course, and modulated Th2, Th1 and Treg function.
For example, the finding that loss of Cdk5 causes frank neurodegeneration with tissue atrophy even in the absence of any detectable effect on apoptosis raises the question of whether treatments aimed at modulating the apoptotic process will be effective in modifying disease course.
In this nationwide prospective study including 147 pregnant RA patients, we examined for the first time whether GR polymorphisms that modulate GC sensitivity are associated with the level of disease activity and disease course during pregnancy and the postpartum period.
Toll-like receptors (TLRs) play a central role in sensing and initiating innate antiviral-response and downstream signaling of TLRs modulates cytokine production, thereby playing an important role in determining the disease course.
Based on the complexities of UTI pathogenesis, the rapid emergence of multi-drug resistant UPEC strains, and the key role the host response plays in the disease course and outcome, interest is growing in the development of treatments that facilitate bacterial clearance by modulating the host immune system.
Piancone, F. et al. B lymphocytes in multiple sclerosis: bregs and BTLA/CD272 expressing-CD19+ lymphocytes modulate disease severity.
There is great heterogeneity in disease course.
