Sentence examples for modulate disease activity from inspiring English sources
These findings imply that HIF-1α is involved in the pathogenesis of renal injury, as activation of HIF responses could modulate disease activity at an early stage, when tissue oxygenation is not yet impaired.
Importantly, intermittent suppression of individual targets was sufficient to modulate disease activity and reduce adverse events.
Given the wide range of HIF-regulated biological functions, normoxic stabilization of HIF-1α is likely to modulate disease activity at an early stage before the occurrence of significant hypoxia.
Thus, there is compelling evidence suggesting that the Notch pathway is activated in RA and may modulate disease activities.
Thus, the cell-specific delivery of cytokines to hepatic sinusoidal cells modulates disease activity.
Treatment-naïve patients displayed higher levels of plasma IFN-α compared to SLE patients on treatment (P <0.001) and healthy controls (P <0.001) suggesting an important role of IFN-α in modulating disease activity.
It is remarkable to find such an association in a cross-sectional study because BAFF level could have been modulated by disease activity and perhaps by treatment.
We therefore hypothesised that netrin-1 could modulate leucocyte infiltration and disease activity in a model of inflammatory bowel disease.
We have demonstrated in various autoimmune diseases that HSP-derived epitopes are capable of inducing and modulating specific T-cell responses and that such modulation correlates with disease activity [15], [18], [19].
The main finding of the cross-sectional observational study was that endothelial function in patients with BD is modulated by both clinical disease activity and use of corticosteroids, albeit in an interrelated manner.
These lesions also showed mosaic expression of SNF5 by immunohistochemistry. Therefore, our studies implicate that modest changes in angiogenic regulation interact with perturbations of SWI/SNF complex activity to modulate disease phenotypes.
