In contrast, the Bliss independence model assumes that both drugs modulate different mechanisms (Fitzgerald et al, 2006a).
The knowledge about parasitic diseases at different levels, such as life cycles, structures, molecular biology, development of new drugs and vaccines, and its ability to escape or modulate different mechanisms of defense of its hosts, is essential to better development of therapies and diagnostics.
Function of AMPA receptor is modulated by different mechanisms, including phosphorylation and their membrane expression [8], [9].
First, acknowledging that a gene's expression can be modulated by different mechanisms (e.g. methylation, copy number and microRNA), even if these mechanisms do not have a direct effect on survival, we can still identify genes whose modulated expressions potentially impact survival.
It functions as a ligand-dependent transcription factor with two activation functions (AF-1 and AF-2) which interact with cofactors (SRC-1, GRIP1, CBP/p300) to modulate transcription using different mechanisms [ 1, 2].
All together, it appears that mitogen induced lymphoproliferation and allo-antigen driven lymphoproliferation are modulated probably by different mechanisms unique for BMMSCs and WJMSCs.
Subsequent studies showed that the PIAS family of proteins modulated transcription by different mechanisms, such as regulation of DNA-binding activity of transcription factors, recruitment of either corepressors or coactivators or engage in post-translational modification by their SUMO E3 ligase activity (Bischof et al, 2006; Wilkinson and Henley, 2010).
PRKCZ expression profoundly affects cellular behaviour (Le Good and Brindley, 2004; Xin et al, 2007), particularly in a diverse range of malignancies (Liu et al, 2009; Wu et al, 2009) where it modulates different biological mechanisms (Della Peruta et al, 2010; Luna-Ulloa et al, 2011; Valkov et al, 2011; Yu et al, 2011).
Nocturnin's peak expression time in the white adipose tissue of restricted fed mice is six hours later than the peak expression time in the liver, implying that different mechanisms modulate this effect.
Interestingly, the signaling pathways activated by acetate and ethanol seemed to modulate H3K9-ac via different mechanisms.
Interestingly, epigenetic mechanisms are closely interconnected, and specific miRNAs can modulate epigenetic signatures through different mechanisms, including targeting of methyltransferases [ 45].
