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In conclusion, the present results suggest that anandamide, an endogenous cannabinoid ligand, may modulate cough sensitivity and anandamide transporters play an important role in this modulation.
These results suggest that anandamide, an endogenous cannabinoid ligand, may modulate cough sensitivity and that anandamide transporters play an important role in this modulation.
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Histamine also plays an important role in modulating cough sensitivity.
These findings suggest that antigen-antibody reaction in the airway is insufficient to modulate cough reflex sensitivity.
Alternatively, inhalation of cold and dry air may induce changes in the airway mucus and modulate cough reflex sensitivity.
We, therefore, carried out this study on the assumption that PDE 3 activity in an asthmatic airway might also lead to increased sensitivity of airway cough response and concluded that a selective PDE 3 inhibitor, cilostazol, can modulate to reduce the airway cough sensitivity to inhaled capsaicin.
Conclusions: Cough sensitivity to inhaled capsaicin is a safe and reproducible tool in the study of chronic cough.
Concentrations that elicited two (C2) and five or more coughs (C5) were determined before and after treatment.Results: In healthy subjects, cough sensitivity to capsaicin was not influenced by gender or smoking status; however, women with chronic cough were more sensitive to cough challenge than men.
Capsaicin cough sensitivity also diminished with treatment.
The cough sensitivity was expressed as the osmolality to provoke 15 cumulative coughs (CUM15).
Cough sensitivity testing was performed according to ERS Cough Taskforce recommendations [ 16].
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