Sentence examples for modulate chromatin structure from inspiring English sources

We also describe how the interpretation of lysine methylation fits into a larger, more complex 'code' of histone PTMs to modulate chromatin structure and function.

Here, we discuss the development of more complex molecules, such as peptides and peptidomimetics, to directly target the nucleosome surface to modulate chromatin structure.

However, they can themselves (epi-miRNAs) repress key enzymes that drive epigenetic remodeling and also bind to complementary sequences in gene promoters, recruiting specific protein complexes that modulate chromatin structure and gene expression.

The mechanisms by which trxG complexes modulate chromatin structure include both non-covalent, ATP-dependent nucleosome sliding and covalent modification of histone tails.

Upon heterodimerization, Myc Max binds specific DNA sites termed E-boxes to activate or repress transcription as well as modulate chromatin structure.

Thus, it is also possible that palladin can shuttle to the nucleus and directly bind to SMC gene promoters to modulate chromatin structure and regulate transcription of SMC marker genes.

Nuclear cofactors function as docking points for various epigenetic regulators such as histone acetyltransferases (HATs) and histone deacetylases (HDACs) that modulate chromatin structures to activate or repress transcription.

Thus the qPCR assay highlights two separate mechanisms for TSA to enhance the luciferase signal of the DMD minigene construct – one as a general effecter of gene transcription by modulating chromatin structure, and another as a modulator of pre-mRNA splicing.

The methylation of lysine residues on histone proteins modulates chromatin structure and thereby contributes to the regulation of DNA-based nuclear processes such as transcription, replication and repair.

One possibility is that Hrp1 may enhance histone deacetylation by modulating chromatin structure at the central core region.

DNA methylation and histone modifications are two important factors in the complex regulatory network modulating chromatin structure and genome function[44].