Sentence examples for modulate chromatin organization from inspiring English sources
Though the mechanisms governing nuclear organization are not well understood, it is apparent that epigenetic modifications coordinately modulate chromatin organization as well as transcription.
To better understand the mechanisms by which Cap-H2 and Mrg15 function together to modulate chromatin organization, we further assessed the interaction between these two proteins and analyzed their localization on chromatin.
Similarly the role of global transcription factors such as SMARCA1, likely to be modulating chromatin organization, is not well understood.
According to this view, Hat1p as a means of modulating local chromatin organization may be just one mechanism among multiple redundant pathways that dictate initiation timing and efficiency at particular origins.
Cohesins are conserved and essential Structural Maintenance of Chromosomes (SMC) protein-containing complexes that physically interact with chromatin and modulate higher-order chromatin organization.
Analysis of their GO terms identified functional modules enriched for chromosome organization, chromatin organization, organelle organization, and chromatin modification.
High-order chromatin organization in mammals is modulated by several epigenetic mechanisms, including DNA methylation and histone post-translational modifications18,19,20.
Interestingly, CENP-C, one of the proteins contributing to centromeric chromatin organization, interacts with DNMT3B and modulates DNA methylation both in centromeric and juxtacentromeric regions [24].
Thus, hypoxia might regulate chromatin organization and gene transcription by modulating WDR5B.
At the rDNA array and centromere central cores, Atf1 mediates Set1 recruitment and modulates H3K4me3 levels that might contribute to proper chromatin organization rather than transcriptional repression itself.
Our data show that stable retroviral integration can lead to alterations of the nuclear chromatin organization, and has the potential to modulate chromatin structure of the host cell.
