Sentence examples for modulate chromatin compaction from inspiring English sources

These modifications to DNA and histones are distributed non-randomly along chromosomes to modulate chromatin compaction and regulate transcription by allowing or inhibiting access of DNA to regulatory proteins.

Interestingly, the H2A NTD is situated in close proximity to the H2B CTD which when ubiquitylated, disrupts chromatin compaction in vitro (Fierz et al., 2011), lending support to the ability of this region of the nucleosome to modulate chromatin compaction.

A single lysyl acetylation on K16 of H4 modulates chromatin compaction and interaction of numerous chromatin-associated proteins; constitutive acetylation of this residue confers a folding defect comparable to deletion of the entire H4 tail.

In turn, these alterations modulate access of sequence-dependent transcriptional regulators to the underlying DNA, the level of chromatin compaction, and communication between distant chromosomal regions [ 18].

Here, we present for the first time chromatin compaction measurements in human lymphocyte cell nuclei for three different, specific gene domains using a novel light microscopic approach called Spatially Modulated Illumination microscopy.

Furthermore, chromatin compaction is predictive of reporter activity.

In contrast, cell degeneration, cell body swelling, and chromatin compaction were observed.

Its recruitment to the DNA is directly regulated by the chromatin landscape, inclusive of chromatin compaction and epigenetic modifications.

Strong acetylation of histones induces relaxation of chromatin structure and is associated with transcriptional activation, whereas weak acetylation leads to chromatin compaction and gene repression (Berger 2007).

The H3K27me3 modification is associated with chromatin compaction and is involved in the transcriptional gene repression.

Depletion of EXPAND1/MUM1 or inactivation of its PWWP domain resulted in chromatin compaction.