Sentence examples for modulate chemosensitivity in from inspiring English sources

However, ZD6474 does not modulate chemosensitivity in parental chemosensitive cells.

Our work provides a rationale for using elongation inhibitors to modulate chemosensitivity in tumors.

To address whether inhibitors of translation elongation could also synergize with DNA damaging agents (e.g. Dxr), we tested the potential of four elongation inhibitors to modulate chemosensitivity in the Eμ-myc model harboring lymphomas with loss of Pten or Tsc2 or over-expressing Bcl-2 or eIF4E.

One flavagline, silvestrol, is capable of modulating chemosensitivity in a mechanism-based mouse model.

In this model, activating lesions in PI3K/AKT/mTOR signalling not only accelerate tumorigenesis, but also modulate chemosensitivity [4], [5], [6].

In addition, a shortcoming of these assays is that they do not assess for a compounds' ability to modulate chemosensitivity.

eIF4E is oncogenic in vivo and in Eμ-Myc lymphomas over-expressing this factor, rapamycin is unable to modulate chemosensitivity whereas silvestrol can [6], [16], [18], [19].

Other in vitro studies have shown that increased miR-21 expression promoted invasion and metastasis and could modulate chemosensitivity (Asangani et al, 2008; Blower et al, 2008; Zhu et al, 2008).

On the basis of its ability to block IGF-IR and modulate chemosensitivity, the addition of figitumumab to docetaxel may improve the antitumour activity of single-agent docetaxel.

The factors that determine chemosensitivity in p53-defective tumor cells are poorly understood.

Conclusion: Our data do not support the hypothesis of a generalized increase in chemosensitivity in early pregnancy.