Sentence examples for modulate channel trafficking from inspiring English sources

To verify whether p.K346T mutation influenced Kir2.1 interactions with proteins known to modulate channel trafficking and/or plasma membrane stabilization (15, 21, 22), we used the His-affinity co-purification system and WB analysis as previously described (23, 24).

AMPA receptor auxiliary subunits, TARPs and CNIHs, control receptor function by modulating channel trafficking and kinetics.

One α-subunit alone is necessary and sufficient to form a functional channel; however α-subunits also associate with β-subunits (SCN1B to SCN4B), which modulate channel biophysics and trafficking.

Since Cav-1 and Cav-2 can modulate channel endocytosis leading to channel degradation or inactivation (31– 36, 36) and Cav-2 can also regulate membrane protein trafficking independently from Cav-1 (37), the results obtained here suggest that the differences in the associations with Cav-2 could influence K346T channels' membrane compartmentalization, stability and trafficking.

We characterize an outwardly rectifying Cl- channel in rodent neocortical cultured astrocytes and describe how cell shape and cytoskeletal actin modulate channel gating.

It's possible that TRPC channel trafficking to the surface may be subject to other signals, such as Gq-coupled receptor/PLC cascades that have been shown to activate TRPC channels and modulate neuronal plasticity in the HIP and cortex [37] [39].

The β subunits, which bind to α subunit covalently or non-covalently, modulate membrane trafficking, voltage dependence, and channel gating kinetics (Catterall, 2012b, 2014).

In addition to the various signaling pathways that may modulate the channel activity, ion channel activation also involves subunit assembly/disassembly, trafficking, insertion and endocytosis of functional channel to/from the plasma membrane.

To extend optogenetic approaches to the immune system to remotely control immune responses with superior spatiotemporal precision, pioneering tools have recently been crafted to modulate lymphocyte trafficking, inflammasome activation, dendritic cell (DC) maturation, and antitumor immunity through the photoactivation of engineered chemokine receptors and calcium release-activated calcium channels.

Apolipoproteins and apolipoprotein mimetic peptides modulate phagocyte trafficking through chemotactic activity.

These changes are likely to modulate the trafficking properties of RIFIN proteins.