Sentence examples for modulate cellular sensitivity from inspiring English sources
Taken together with the previous results, these findings suggest that (1) both BRCA genes modulate cellular sensitivity to I3C and (2) the modulation of sensitivity to I3C by BRCA1 is due, in part, to alterations in BRCA2 levels.
The ability of 1,9-dideoxyforskolin (DDF), 1-deoxyforskolin (DF) and forskolin to modulate cellular sensitivity to vinblastine (VBL) was examined in drug-sensitive parental KB-3-1 cells and a multidrug-resistant subline, KB-GRC1, derived by transfection of mdr1.
Since deregulation of specific miRNAs has the consequence of changing cell survival after irradiation, this might represents a possible strategy to modulate cellular sensitivity to anti-cancer treatments.
Alterations to the ratio of G F actin at the site of PPP1R15 action were seen to modulate cellular sensitivity to ISR stimuli via changes in eIF2α phosphatase activity.
Here, we describe the identification and characterization of the two key enzymes in arginine biosynthesis, ASS1 and ASL, as epigenetically regulated genes in GBM, and we demonstrate that epigenetic changes in these changes modulate cellular sensitivity to therapeutic autophagy.
We then used this model system to reveal key differences in the response of sensitive and resistant cell lines to HDACi that impact cell cycle progression and may modulate cellular sensitivity to the pro-apoptotic effects of these drugs in DLBCL.
Taken together, the data support a role for miR-26b-mediated Mcl-1 regulation that modulates cellular sensitivity to TRAIL.
Apart from mtDNA mutations and respiratory dysfunction, ROS and cellular redox homeostasis also play a critical role in determining and modulating cellular sensitivity to drugs.
We have also shown that the autoimmune disease associated variant of signal transducer and activator of transcription 4 (STAT4) modulates cellular sensitivity to IFN-α signaling [ 19].
Moreover, SnoN alters cellular sensitivity to apoptosis by modulating LC3-II levels.
We present evidence that expression of DUSP16 expression selectively modulates the activation of JNK and influences cellular sensitivity to chemotherapeutic agents.
