TIMPs can modulate cellular processes such as cell growth, apoptosis and migration, and can be both anti- and pro-tumorigenic.
In recent years, sirtuins (SIRTs), members of histone deacetylases (HDACs) class III, have been found to modulate cellular processes related to the development of human aging-related pathologies (i.e. cancer, neurodegeneration, metabolic disorders).
They are involved in cell cell recognition and modulate cellular processes that range from the shaping of tissue architecture and neovascularization to the regulation of insulin homeostasis and T-cell proliferation.
PRDM genes are a family of transcriptional regulators that modulate cellular processes such as differentiation, cell growth and apoptosis.
Further, the conformational state of TG2 is likely an important determinant in cell survival and the prominent function of TG2 in ischemic cell death is as a scaffold to modulate cellular processes.
However, our results suggest that, even at low levels, radiation is able to modulate cellular processes.
This increase, in turn, modulates cellular processes such as regulation of Ca2+-dependent channels, mediating neurotransmitter release, possibly influencing generation of action potentials [5], and stimulating intracellular signalling enzymes and gene expression [6], [7], [8], [9], [10], [11].
It is now increasingly recognized that OxPL are not just by-products of lipid peroxidation associated with inflammatory conditions or increased oxidative stress, but instead actively modulate cellular signaling processes and contribute to the initiation and amplification of inflammation.
It is now increasingly recognized that oxidized phospholipids (OxPL) do not just represent mere by-products of lipid peroxidation associated with inflammatory conditions or increased oxidative stress, but instead actively modulate cellular signaling processes and contribute to the initiation and amplification of inflammation (Berliner & Watson, 2005; Bochkov et al, 2010; Lee et al, 2012).
However, TG2 has other enzymatic activities in addition to its cross-linking function and can modulate multiple cellular processes including apoptosis, autophagy, energy production, synaptic function, signal transduction and transcription regulation.
Sphingolipid (SL) metabolism is a complex biological system that produces and transforms ceramides and other molecules able to modulate other cellular processes, including survival or death pathways key to cell fate decisions.
