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Together, our findings reveal the histone chaperone CAF-1 to be a novel regulator of somatic cell identity during transcription-factor-induced cell-fate transitions and provide a potential strategy to modulate cellular plasticity in a regenerative setting.
In this Perspective, we synthesize past and present observations in the field of epigenetics to propose a model in which the epigenome can modulate cellular plasticity in development and disease by regulating the effects of noise.
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Carrier size, shape, and plasticity modulate cellular uptake and trafficking.
These findings demonstrate that REPs possess cellular plasticity, and suggest that the phenotypic transition of REPs to myofibroblasts, modulated by inflammatory molecules, underlies the connection between anemia and renal fibrosis in CKD.
The epigenetic basis of cellular plasticity.
Each domain interacts with various effectors to modulate cellular functions.
Wainwright, E. N. & Scaffidi, P. Epigenetics and cancer stem cells: unleashing, hijacking, and restricting cellular plasticity.
Ritschka, B. et al. The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration.
Ninov, N. et al. Metabolic regulation of cellular plasticity in the pancreas.
Totipotent and pluripotent cells display different degrees of cellular plasticity.
Meinert, C. et al. Tailoring hydrogel surface properties to modulate cellular response to shear loading.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com