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The surface coatings play an important role in determining the nanoparticle toxicity, which in turn modulate cell uptake and biological responses, consequently impacting the potential safety and efficacy of nanomaterials.
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Fig. 8 Cell uptake study.
Cell uptake is predominantly mediated by endocytosis.
It is known that nanoparticles (NPs) can modulate cell fate, induce or prevent mutations, initiate cell cell communication, and modulate cell structure [7, 8].
Figure 3 Cell uptake and washout study.
Fig. 3 Cell uptake of the nanoparticles.
Figure 1 Cell uptake and inhibition studies.
We modulate cell redox state in several experiments.
All tested compounds exhibited efficient cell uptake.
Oxymetholone (1) is known to modulate cell-mediated immunity in vivo.
Endocytosis directly (and indirectly) affects responses to guidance cues and growth factors, the uptake of nutrients and even pathogens; it modulates cell signalling in response to receptor activation and is essential for cell migration.
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