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A major issue is whether the spatial organization of a cell within this 3D tissue microenvironment could modulate cell responsiveness to regulate cell fate decisions such as survival, and if so how.
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IL-6 pretreatment of normal cells reduced IL-10-mediated inhibition of IFN-γ production (Fig. 5b), indicating that high concentrations of IL-6 could modulate T-cell responsiveness to IL-10.
The predominant intracellular localization of CXCR4 suggests that the dynamic equilibrium between the plasma membrane and cytoplasm can modulate CXCR4 availability at the cell surface, which in turn regulates cell responsiveness to follow a CXCL12 concentration gradient.
Interestingly, endothelial cell VEGF expression can alter mural cell responsiveness to PDGF via growth factor crosstalk, modulating mural cell recruitment and mural function [10].
It is known that nanoparticles (NPs) can modulate cell fate, induce or prevent mutations, initiate cell cell communication, and modulate cell structure [7, 8].
By defining the cell cycle position on a cell-by-cell basis, we next determined cell responsiveness to compounds.
Fasting (M0) and postprandial beta cell responsiveness (M1) were calculated.
Meniscal cell responsiveness to TGF-β was also investigated.
The mean fasting beta cell responsiveness (M0) was 1.32 ± 1.71 and postprandial beta cell responsiveness (M1) was 4.42 ± 4.62.
ROS induces cell death by modulating cell signaling pathways.
Cellular O-GlcNAc levels respond to environmental and nutrient stress in animal cells, and increasing global levels of O-GlcNAc-modified proteins increases stress tolerance and modulate the responsiveness of cells to extracellular signaling [47].
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CEO of Professional Science Editing for Scientists @ prosciediting.com