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We use the unique characteristics of small molecules to probe and selectively modulate cell motility.
Loss- and gain-of-function studies demonstrate the ability of T-cadherin to modulate cell motility and growth.
Manipulations that change the stiffness of these 3D scaffolds often alter other matrix parameters that can modulate cell motility independently or synergistically, making observations less predictive of how cells behave when migrating in 3D.
Recently, it has been demonstrated that the tumor suppression function of p27 resides not only in the ability to inhibit Cyclins/CDKs complexes through its N-terminal domain but also in the capacity to modulate cell motility through its C-terminal portion.
Stress fibers in turn modulate cell motility and spreading.
Cell surface RHAMM can interact with the second specific hyaluronan receptor [ 141, 142], CD44, and modulate cell motility, wound healing, and signal transduction.
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The enzyme modulates cell motility and plays an important role in tumour invasion and proliferation.
Four and a half LIM domain protein-2 (FHL2) is part of the focal adhesion structures modulating cell motility.
Dysregulation of Src has been linked to oncogenesis process for many years [52], and it is also known to play a role in metastasis by modulating cell motility and invasive abilities in skin, breast and colon cancers [53].
The mechanisms whereby S100A4 modulates cell motility are unknown.
The actin binding protein CapG modulates cell motility by interacting with the cytoskeleton.
More suggestions(15)
modulate cell colonization
modulate cell envelope
modulate cell commitment
modulate cell physiology
modulate cell cycle
modulate cell surface
modulate cell density
modulate cell differentiation
modulate cell death
modulate cell phenotype
modulate cell viability
modulate cell injury
modulate cell response
modulate cell metabolism
modulate trophoblast motility
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