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It has been shown that HSPGs may modulate cell migration by interacting with growth factors or chemokines and drives cell migrate toward specific stimuli [ 44].
Through this latter mechanism, SMARCA4 may serve to modulate cell migration and reduce the potential for invasion.
Also microbial factors like phospholipase C and LPS have been found to modulate cell migration (Firth et al. 1997; Häkkinen et al. 2000; Koff et al. 2006).
Integrins play a key role in angiogenesis and tumor metastasis by mediating tumor cell invasion and movement across blood vessel, whereas integrins expressed on endothelial cells modulate cell migration and survival during the angiogenic cascade.
The ability of p27 to modulate cell migration has been previously ascribed by its ability to bind other proteins more directly implicated in the regulation of cellular motility, namely RhoA and stathmin [17], [19] [21].
Thus, AhR and Cav-1 could be acting in concert to modulate cell migration during normal and pathological situations.
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Stimulation of beta 1 integrin induces tyrosine phosphorylation of vascular endothelial growth factor receptor-3 and modulates cell migration.
Wang, J. F. Stimulation of β1 integrin induces tyrosine phosphorylation of vascular endothelial growth factor receptor-3 and modulates cell migration.
Furthermore, we detected upregulation of p-70S6K and p-Akt in GPCs transduced with NF1-shRNA, confirming the observation of Qian et al. that AKT modulates cell migration and invasion through the activation of p-70S6K.
LASP-1 knock out mice exhibit enhanced wound healing and rapid tumor initiation, consistent with the idea that LASP-1 modulates cell migration [47].
Apart from its role in modulating cell migration and cell death, src42A also regulates JNK-dependent dorsal closure.
More suggestions(16)
modulate keratinocyte migration
modulate cell adhesion
modulate cell colonization
modulate proliferation migration
modulate cell envelope
modulate cell cycle
modulate cell physiology
modulate cell differentiation
modulate cell death
modulate cell phenotype
modulate cell viability
modulate cell injury
modulate cell response
modulate cell motility
modulate cell metabolism
modulate enterocyte migration
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