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Finally, we demonstrate that ligation of CD81 by E2661 induced aggregation of lymphoid cells and inhibited B-cell proliferation, demonstrating that E2 interaction with CD81 can modulate cell function.
This strategy may represent the next paradigm in our ability to modulate cell function and offers a unique avenue for the treatment of disease.
The study of how physical and biochemical signals collectively modulate cell function not only brings forth a more holistic understanding of cell (patho biology, but it also creates opportunities to control material properties to improve culture platforms for research and drug screening and aid in the rationale design of biomaterials for molecular therapy and tissue engineering applications.
Moreover, in response to metabolic and genetic stress mitochondria and nucleus engage in bidirectional signaling pathways, which modulate cell function [4, 34, 35].
Thus, taken together these data suggest that L1 is able to regulate sialylation and fucosylation to modulate cell function via a PLCγ dependent pathway.
A number of important questions remain to be addressed in our understanding of how RLS modulate cell function.
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The killer cell Immunoglobulin-like receptors (KIR), expressed on the surface of natural killer cells, modulate cell functions by their interaction with class I human leukocyte antigen (HLA) molecules.
In various cell types, NF-κB and COX-2 are regulated by ROS, which modulate cell functions such as inflammation, cell growth, and motility [35], [36].
Due to their expression patterns, interactions with cell surface proteins, and the ability to modulate cell functions, members of the CCN family have also been described as matricellular proteins [ 10].
However, small chemical compounds are much safer and have shown more advantageous in modulating cell function and cell fate changes (Xu et al., 2008).
Extracellular matrix, in addition to cardiac cells, is essential to maintain the integrity of cardiac tissue and plays an important role not only in providing structural and mechanical support but also in modulating cell function.
More suggestions(15)
modulate cell colonization
modulate cell envelope
modulate cell commitment
modulate cell physiology
modulate cell cycle
modulate protein function
modulate cell differentiation
modulate cell phenotype
modulate cell death
modulate cell viability
modulate cell injury
modulate cell response
modulate cell motility
modulate cell metabolism
modulate brain function
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