The amount of AhR that is present in the nuclear and cytoplasmic compartments of the cell is modulated by cell density in keratinocytes [ 31] and hamster fibroblasts [ 5].
Conversely, the activity of the −48/+43 promoter construct was not modulated by cell density, suggesting that the density-responsive regulatory region is localised upstream of the nucleotide −48.
Oleic acid may have a role in inflammation as topical application modulates epidermal Langerhans cell density.
Previous studies reported that cell density modulates the intracellular localization of AhR in keratinocytes [ 31] and in 10T1/2 fibroblasts [ 5] so that low cell densities kept AhR in the nucleus while higher confluences induced its accumulation in the cytoplasm.
Sodalis glossinidius, an endosymbiotic bacterium found in tsetse flies (Glossina spp ., uses an AHL-based quorum sensing system to modulate gene expression according to cell density.
While it is not known how increased cell density could specifically modulate behaviours relevant to WBS, cortical processing of sensory input altered by this mechanism, in principle, could subserve the enhanced sensory processing and even sensory-dependent social behaviour observed in the PD animals.
These observations indicate that ATF4 protein level is modulated by signals derived from both cell density and DMI cocktail, leading to functional interaction with C/EBPβ in primed hMSCs as well as early in adipogenesis.
Moreover, immunohistochemical analysis of the tumors confirmed a positive correlation between macrophage and mesenchymal tumor cell density, suggesting that TAMs modulate the phenotype of tumor cells located in the neighboring microenvironment.
Bacteria communicate through a process named quorum sensing (QS) to modulate gene expression in response to changes in cell density.
As cell density has been reported to modulate p185c- erb B-2 levels in breast cancer cells (Kornilova et al, 1992), we compared the oncoprotein levels in low (50% confluence)- and high (100% confluence -density confluence -density
