Sentence examples for modulate cell death from inspiring English sources

We concluded that TNZ is genotoxic, cytotoxic and is able to modulate cell death through apoptotic mechanisms in the experimental design employed.

Disruption of heterodimerizations by small-molecule inhibitors could be used to modulate cell death in both cancer (to increase apoptosis) and degenerative disorders (to decrease apoptosis), and assays are necessary to screen compound libraries.

Here, we demonstrate that the central mechanisms of PEI architecture- and size-dependent perturbations of integrated cellular metabolomics involve destabilization of plasma membrane and mitochondrial membranes with consequences on mitochondrial oxidative phosphorylation (OXPHOS), glycolytic flux and redox homeostasis that ultimately modulate cell death.

A primary role of TG2 in the cell is to modulate cell death processes.

To assess whether IGFBP3 overexpression could modulate cell death, hIGFBP3 transgenic mice were crossed with Hcrt-ataxin-3 transgenic mice known to develop hypocretin cell loss at 3 6 weeks of age.

[53] Another group of ER based proteins found to interact with Bcl-xL and/or Bcl-2 and to modulate cell death is composed of members of the Reticulon family of proteins: RTN1-C, RTN4A and RTN3.

During infection by Xcv, the virulence factor FILAMENTOUS HAEMAGGLUTININ ADHESIN 1 (Fha1) targets CaHIR1 where it modulates cell death and suppresses pepper PR gene expression (Choi et al. 2013).

Finally, targeting the specific targeting of cholesterol to mitochondria may be an additional approach of potential benefit in cancer treatment by modulating cell death and chemotherapy resistance.

Although in the serum of patients affected by acute myocardial infarction (AMI) several cytokines, including those belonging to the TNF family members, are known to be elevated [1], only limited information is available on the role of TNF family members in modulating cell death after myocardial ischemia [2] [4].

ACD2 modulates cell death in Arabidopsis infected with P. syringae.

The mitochondrion is a widely used target by many pathogens for modulating cell death.