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The ECM relays both biochemical and biophysical cues to and from the cells to modulate cell behavior and function.
Vice versa, the ECM exhibits unique mechanical signatures associated with its fibrous polymer network that can modulate cell behavior.
TSPs are multifunctional and modulate cell behavior during development, wound-healing, immune response, tumor growth and in the homeostasis of adult tissues.
Furthermore, the degree of enzymatic crosslinking of the gelatin-Ph hydrogels could be used to modulate cell behavior and the extent of vascular network formation in vivo.
Recent trends in scaffold design have focused on materials that can provide appropriate guidance cues for particular cell types to modulate cell behavior.
Objective The interactions between integrins and extracellular matrix proteins are known to modulate cell behavior, and may be involved in regulating cartilage formation and repair.
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Basement membranes (BMs) are specialized extracellular scaffolds that provide architecture and modulate cell behaviors in tissues, such as fat, muscle, endothelium, endometrium, and decidua.
The nanofibrous topography itself, independent of the fiber material, has demonstrated the potential to modulate cell behaviors desirable in tissue engineering such as: unidirectional alignment; increased viability, attachment, and ECM production; guided migration; and controlled differentiation.
Ligation of integrins triggers a large variety of signal transduction events that serve to modulate cell behaviors including proliferation, survival/apoptosis, shape, polarity, motility, gene expression, and differentiation.
Currently at least 21 proteins are reported to bind to one or more of the integrin β tails and modulate cell behaviors including cell migration, adhesion, and fibronectin matrix assembly [4].
Polymeric nanofibers display unique mechanical properties, which are useful for modulating cell behavior as well providing adequate strength and tension to the cells seeded into the scaffolds.
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