Sentence examples for modulate brain endothelial from inspiring English sources

We have previously reported that cytokines differentially modulate brain endothelial and gliovascular barrier responses [ 24].

These soluble factors would then act on pericytes, inducing them to release soluble factors that would modulate brain endothelial cell transcytosis of I-HIV.

Hence, it becomes apparent that several intercellular signaling mechanisms might operate in the neurovascular and gliovascular units that can potentially modulate brain endothelial responses to leukocyte recruitment during cerebral ischemia.

The role of neurovascular and gliovascular uncoupling in modulating brain endothelial properties during cerebral ischemia is not clear.

It is also clear that while aglycemia plays a major role in modulating OGDR astrocytic and neuronal barrier, hypoxia plays a prominent role in modulating brain endothelial angiogenic potential by OGDR astrocytes and neurons.

While several treatment combinations may be required to further understand the roles of these ECAM modulation by neurovascular and gliovascular units in initiation and propagation of leukocyte interactions, our current study provides a basic understanding on how metabolic stresses can affect neuronal and astrocytic interactions in modulating brain endothelial interactions with lymphocytes.

Previous research from our laboratory has demonstrated that PCBs can modulate properties of brain endothelial cells in vitro and enhance adhesion and transendothelial migration of tumor cells (Choi et al. 2003; Eum et al. 2004, 2006).

We recently showed that the miRNA expression profile of HBMVECs was modulated upon exposure of these brain endothelial cells to glioblastoma cells [11].

Recent observations support the notion that engagement of ARs on brain endothelial cells modulates BBB permeability in vivo.

LPS should also prove useful for studying the cells that influence and modulate the BBB that together with brain endothelial cells form the neurovascular unit.

In the present study using 3D co-culture system with endothelial cells/neurons and endothelial cells/astrocytes representing intimate neurovascular and gliovascular coupling, we investigated the role of metabolic stresses in modulating neurovascular and gliovascular responses in affecting brain endothelial barrier, angiogenesis and leukocyte interactions via ECAM expression.