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Therefore, we hypothesized that PHGDH may modulate autophagy in ECSLCs.
We show that raw-DWCNTs could also modulate autophagy in tumor cells through induction of intracellular acidification.
To the best of our knowledge, this is the first time that DWCNTs have been found to inhibit proliferation and modulate autophagy in cancer cells.
Hence geldanamycin derivatives may provide a means to modulate autophagy in neural cells, thereby ameliorating pathogenic aggregate formation and protecting the cells during disease and aging.
These lncRNAs modulate autophagy in different ways.
Cardiac glycosides modulate autophagy in different experimental settings.
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We list MTOR as a negative modulator because it negatively modulates autophagy in the presence of sufficient nutrients.
To understand the mechanism by which PHGDH modulates autophagy in ECSLCs, we probed the mTOR signaling pathway, as phosphorylated mTOR (p-mTOR) is a major negative regulator of autophagy following various stress-inducing stimuli, such as energy and nutrient deprivation38.
These outcomes provide a better understanding of the role of Nrf2 in modulating autophagy in an AD mouse model and may help design better Nrf2 targeted therapeutics that could be efficacious in the treatment of AD.
To further investigate the manner in which HIV-1 modulates autophagy in non-infected cells we examined signaling molecules upstream of Akt.
Reciprocally, frataxin expression modulates autophagy in the absence of p53.
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