Sentence examples for modulate assembly of from inspiring English sources
While structure-based drug design has revolutionized the potentials for therapeutic intervention of native proteins, IMS MS offers new opportunities for developing and characterizing small molecules able to bind and modulate assembly of highly dynamic, non-native states.
Rac1 is key regulator of the actin cytoskeleton, cell motility, junction assembly and stability and can modulate assembly and disassembly of adherens junctions [ 28- 32].
Moreover, many TJ proteins are targets of protein kinases, which modulate assembly, stability and functional properties of TJs [ 4].
It should be further noted that DMEM is known to contain a wealth of ions, amino acids, and other compounds needed for the sustenance of cultured cells, exemplifying an environment that is most likely to be found in vivo; in turn, the charged and organic substrates contained in DMEM may very well modulate the assembly of nanoparticles!
And in fact bacteria use the cycle of nucleotide hydrolysis to modulate the assembly of their cytoskeletal filaments quite nicely.
With 'inside-out' signaling, integrin activation might modulate the assembly of ECM ligands on the cell surface.
In addition to these functions, Cbl proteins modulate the assembly of signaling proteins downstream of the M-CSF receptor (c-Fms) and RANK that are required for osteoclastogenesis.
The methylation of arginine residues within the RGG domains of FUS has been proposed to modulate the assembly of FUS into stress granules.
This finding suggests that oxidative modifications of C361 can reversibly modulate the assembly of the ternary complex and that a C361A mutation can confer redox-insensitivity to Brf2.
Recent studies suggested that some multi-subunit tethering complexes could also directly modulate the assembly of functional SNARE complexes (reviewed in Hong and Lev, 2014).
Hence, remodeling of the actin cytoskeleton architecture depends on a large group of signaling molecules that bind to actin and modulate the assembly of the actin network (see [ 1] for a comprehensive overview).
