Studies of p53-mediated repression have shown that both genes that modulate apoptotic responses and genes that promote cell cycle progression can be repressed by p53 [ 4].
The PKC δ and η also modulate the apoptotic response of keratinocytes exposed to UVB [36], [37].
We then investigated the potential mechanism by which cyclin D1 might modulate the apoptotic response.
Substantial data support a role for mTOR signalling through the eIF4E pathway in promoting cell survival, although exogenous factors may modulate the apoptotic response to mTOR inhibition.
We then used a transplantation and a pharmacological approach to provide evidence that a disrupted microenvironment and endothelial apoptosis after irradiation might modulate the apoptotic response of NPCs in vivo.
In the case of Drosophila, unlike mammals or worms, the Bcl-2 proteins are not involved in regulating developmental programmed cell death (PCD), but modulate the apoptotic response to stress [ 11- 13].
All together, these results showed that M1 and M2 macrophages differentiated and polarized from THP-1 monocytes modulate the apoptotic response to etoposide of two cancer cell lines, HepG2 and A549 cancer cells.
Both triterpenes successfully modulated the apoptotic response, promoting nuclear condensation and fragmentation.
Future work will need to be done to clarify the mechanistic role of the hypoxia/HIF-1 pathway in modulating the apoptotic response of NPCs after irradiation.
In previous studies by our group, sTRAIL had activity against glioma cells in vitro and demonstrated the interaction of the death and survival pathways in modulating the apoptotic response.
