This death was inhibited by the caspase inhibitor ZVAD-fmk, again supporting a role for PTK6 in modulating apoptosis of breast cancer cells under matrix-detached conditions.
As phosphorylation events are known to modulate apoptosis, phosphorylation of Bax in Ser184, probably by Akt, inhibits effects of Bax in mitochondria and prevents the induction of apoptosis.
In one report, a dissociation between the ability of Bcl-xL to modulate apoptosis and invasiveness of human glioma cells was observed [29].
In the present report, we investigated the capacity of CD40L to modulate apoptosis induced by a variety of cytotoxic agents with different modes of action in breast and NHL cell lines.
Conversely, the autophagy machinery may modulate apoptosis by autophagic degradation of apoptotic proteins.
Inhibitors of tyrosine kinases were shown to modulate apoptosis induced by a variety of agents in different cell types (Uckun et al, 1992; Bergamaschi et al, 1993; Liu et al, 1994; Ji et al, 1995).
While it is well-known that HSVs modulate apoptosis [ 11, 12, 46], details of the triggering and prevention mechanisms still remain fragmented.
It codes for a zinc finger protein and transcriptionally regulates a panel of genes to modulate apoptosis and cell cycle [ 9].
Rather, Bortezomib modulates apoptosis sensitivity of cancer cells in a context-dependent manner, depending on, for example, the cytotoxic stimulus, cell type, administration schedule and so on.
