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A previous analysis of these mice showed that AID can modulate apoptosis in vivo.
Alpha1-acid glycoprotein is increased in response to systemic infection and has been shown to modulate apoptosis in bovine monocytes, probably through caspase-3 inhibition and caspase-9 activation [22].
MAPKs have been reported to modulate apoptosis in the heart.
This difference could reflect the involvement of other pathways that modulate apoptosis in E1A-transfected cell lines.
These reports therefore suggest that Beclin 1 may modulate apoptosis in cell-specific and stimuli-specific patterns.
More relevantly to the subject of this review it is well known that bacteria can modulate apoptosis in the host favoring their survival and propagation.
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Song, M. Q. et al. Synergistic effect of oxymatrine and angiogenesis inhibitor NM-3 on modulating apoptosis in human gastric cancer cells.
In addition to modulating apoptosis in tumor cells, there have been reports that Bcl-2 family members can additionally promote carcinogenesis via effects on tumor cell invasion [28] [31].
Together, these results demonstrate that autophagy plays an important role in modulating apoptosis in response to IFN1@.
Furthermore, experimental studies with macrophages demonstrated an involvement of NR4A1 in modulating apoptosis in the inflammatory response.
Overall, the data suggest that curcumin modulates apoptosis in THP-1 cells via the activation of JNK/ERK/Jun pathways.
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