Sentence examples for modulate and increase from inspiring English sources

One interesting aspect relates to the potential that hypoglycaemia, in particular severe hypoglycaemia, may modulate and increase CV risk.

Based on our results and summarized in Figure 8d, we propose that in addition to promoting myogenesis, NF- κB blockade increases HGF expression by myogenic cells during repair, which acts locally to modulate inflammation and increase cell survival.

23– 31 All these activities are modulated and increased by the chitin nanofibrils (CN) encapsulation methodology.

The interaction of antigen with IgE bound to FcεRI triggers mast cells to degranulate, resulting in the release of increased levels of mediators that modulate immune responses and increase smooth muscle contraction and vascular permeability [ 89].

Here, we aimed to determine whether the IGFs interact with the placental RAS in early to mid gestation to modulate placental development and increase fetal growth and survival, and if IGF2 binding the IGF2R is implicated in the sustained effects of IGF2 treatment.

Recent studies have indicated that infiltrated inflammatory cells produce various reactive oxygen species, pro-inflammatory cytokines, matrix metalloproteinases (MMPs), and transforming growth factors, which modulate local response and increase inflammation [25].

Differential expression is expressed as ΔCt (abbreviated DCt), which represents (meanCtMed_Norm_AC) - (meanCtMed_Norm_Con). The third method employed the Integromics Statminer package, which uses a Limma-based empirical Bayesian implementation to calculate a hyperparamter which is in turn used to modulate the variance and increase the degrees of freedom across the samples.

NGF is also thought to alter expression of neurotransmitters, modulate ion channels, and increase excitability of afferent nerves [ 57].

Consequently, stimulation of chondrocytes with natriuretic peptides and mechanical signals may potentially serve to modulate cell proliferation and increase matrix synthesis in the OA joint.

However, it has also been reported that HDAC6 knockdown increases mutant Cu Zn superoxide dismutase (SOD1) aggregation in cultured cells and mutant G93A-SOD1 can modulate HDAC6 activity and increase tubulin acetylation.

In addition to gene therapy, a class of novel small molecules, acting as allosteric compounds, is under development and in preclinical models have been found to modulate SERCA2a activity and increase Vmax and contractility without increasing energy utilization, making them important candidates as new IV inotropic drugs.