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It is reasonable that parallel signaling systems exist to modulate and fine-tune the many responses attributed to cytokinins.
Interestingly, miRNAs usually affect target gene expression in the range of 1.2-4.0 1.2-4.0suggesting that, rather than foldsioning asuggestingwithats forathers, than modulate and functioninghe expression of tasget genes.
As with the "quasi-species" defined for RNA viruses [ 75], this gives the cell the potential to respond rapidly to a changing environment via the selective ribosomal recruitment (transcript filtering) of pre-existing transcripts variants that modulate and "fine-tune" the translational readout and hence the proteome.
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Using systems-level inputs as a starting point, we were able to modulate key TFs that cause suboptimal cellobiose fermentation and fine-tune the expression of the heterologous cellobiose-consumption pathway, greatly improving cellobiose fermentation by engineered S. cerevisiae.
Thus, no further attempts to optimize and fine-tune these ammonium salts were undertaken.
Equally, these variants can be used to optimize and fine-tune the expression of therapeutic proteins.
Summarizing the ongoing exploratory study mainly aims to further develop and fine-tune both tools.
MicroRNAs simultaneously target many transcripts and fine-tune the expression of genes through cooperative/combinatorial targeting.
A pretest of the program then was carried out to further adapt and fine-tune it.
A similar small magnitude of change in MeCP2 target genes was also detected using ISH studies (39, 40); suggesting that MeCP2 modulates gene expression and fine-tunes levels of its target genes rather than causing large fold changes.
Co-regulation of alternative splicing of multiple genes in pathways affecting cholesterol metabolism may provide a means to quickly modulate or fine-tune the effects of SREBP-mediated transcriptional regulation of intracellular cholesterol content.
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