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NK cells may modulate allergic responses through their interactions with DCs, which are important cells in initiating and shaping adaptive immune responses.
CLRs also initiate and modulate allergic responses.
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Immunotherapy (IT) is designed to modulate allergic airway response.
To this point, we demonstrated that GO was able to modulate allergic immune response in a murine model of OVA-induced asthma.
As areca nut extracts have been shown to affect the functionality of mast cells and lymphocytes that are key players involved in the pathophysiology of type I hypersensitivity, we hypothesize that areca-derived polyphenols may be effective in modulating food allergic responses.
Engineered hypoallergens with reduced reactivity for IgE antibodies are being examined to modulate the allergic response and develop prophylactic allergen vaccines.
These substances have been shown to modulate the allergic response, however a consensus has yet to be reached whether they attenuate or exacerbate asthmatic responses.
Others have shown that oral administration of L. reuteri modulates allergic airway responses in mice (Forsythe et al. 2007; Karimi et al. 2009).
Ultrafine particles present in ambient air have, in animal models and in humans, been demonstrated to modulate airway inflammations and promote allergic responses in the lung [ 1– 4].
THE BOTTOM LINE Studies show that psychological stress can heighten and possibly prolong allergic responses.
Allergic responses differ from the usual toxic responses in three ways.
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